Donald Trump has launched an extraordinary attack on film director Rob Reiner, who was found stabbed to death with his wife on Sunday, as it was revealed his son has been arrested on murder charges.

The US president said in a post on Truth Social that Reiner was “a tortured and struggling, but once very talented movie director and comedy star”.

Mr Trump said Reiner and his wife died “reportedly due to the anger he caused others through his massive, unyielding, and incurable affliction with a mind crippling disease known as TRUMP DERANGEMENT SYNDROME, sometimes referred to as TDS”.

“He was known to have driven people CRAZY by his raging obsession of President Donald J. Trump, with his obvious paranoia reaching new heights as the Trump Administration surpassed all goals and expectations of greatness, and with the Golden Age of America upon us, perhaps like never before. May Rob and Michele rest in peace,” Mr Trump wrote.

Meanwhile, Reiner’s son, Nick, 32, has been “booked for murder” and is being held on $4m bail in connection with the deaths of his parents, Los Angeles police chief Jim McDonnell said.

Mr McDonnell said the department’s robbery and homicide division was handling the investigation.

“They worked throughout the night on this case and were able to take into custody Nick Reiner, a suspect in this case,” he said, calling the deaths “a very tragic incident”.

Reiner and Michele Singer Reiner apparently died of stab wounds, US media reported.

The Los Angeles Fire Department said a 78-year-old man and a 68-year-old woman were found dead inside a property in the Brentwood neighbourhood, without identifying the victims. Other officials confirmed the victims were Reiner and his wife.

Read More: Donald Trump launches attack on Rob Reiner, found stabbed to death, as director’s son is arrested