Electrogenetics, the combination of electronics and genetics, is an emerging field of mammalian synthetic biology. It combines genetics and electronics to influence gene expression through electrical signals. Wearable devices could serve as vehicles for these signals, to activate or silence specific genes, which holds promise for treating diseases caused by gene misregulation and advancing personalized medicine.

Traditional gene editing techniques, such as CRISPR-Cas9, involve modifying the DNA itself. In contrast, electrogenetics seeks to control genes indirectly by manipulating the electrical signals that regulate their activity. This paradigm shift has opened up exciting possibilities for non-invasive interventions.

Wearable devices have already transformed how we monitor our health, from tracking our steps to monitoring heart rate and sleep patterns. The marriage of electrogenetics and wearables takes this a step further, envisioning devices that can communicate with our cells by emitting precise electrical signals that target specific genes, modulating their expression, and potentially rectifying genetic mutations responsible for diseases. This concept taps into the body's natural communication pathways and could be harnessed to correct gene misregulation. The practical applications of electrogenetics and wearable devices in gene control have substantial potential for healthcare. 

Hope for diabetes treatment

Electrogenetic treatment show promise for diabetes treatment. In just four weeks the treated mice could better battle low blood sugar from dieting, and eventually they restored their normal blood sugar levels. They were also adept at regulating blood sugar levels after a meal, something that’s difficult in people with diabetes without insulin.